MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is an experimental mitochondrial-derived peptide. It is widely discussed as an “exercise mimetic” because it mimics the metabolic adaptations of fasting and physical activity, such as activating the AMPK pathway, improving insulin sensitivity, and supporting fat oxidation.
Regulatory and Safety Status
- Not FDA-Approved: MOTS-c is not approved for any therapeutic use in humans. It is considered strictly experimental and is not a standard of
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